Near-net-shape fabrication of open-porous bone replacement materials of calcium phosphate and protein
Zusammenfassung
As today’s synthetic bone implants fulfil the requirements for the repair of bone defects only in part continuous research for their improvement is ongoing. This work aims at the fabrication of bone replacement materials with bone-like properties regarding composition, structure, mechanical stability, and resorbability. As appropriate fabrication method, the slurry-based freeze gelation process was chosen. It allows the direct incorporation of active bio-relevant compounds, such as proteins, during scaffold processing. Moreover, the process enables the fabrication of complex-shaped and open-porous scaffolds. As principal components for the scaffolds calcium phosphate and protein were selected as they are biocompatible and resorbable. This work analyses the interaction between calcium phosphate and protein in suspension and investigates the suitability of the fabricated calcium phosphate/protein scaffolds as bone replacement material and drug release depot.
Table of Contents
SUMMARY ...
Schlagworte
Biocompatibility Bioresorbability Bone Replacement Calcium / Phosphate Freeze Gelation Local Drug Release Lysozyme Serum Albumin Zeta Potential- 4–14 2 BASICS 4–14
- 15–26 3 METHODS 15–26
- 27–38 4 EXPERIMENTAL 27–38
- 39–63 5 RESULTS 39–63
- 64–75 6 DISCUSSION 64–75
- 76–77 CONCLUSIONS 76–77
- 78–78 OUTLOOK 78–78
- 79–80 APPENDICES 79–80
- 81–92 REFERENCES 81–92