Near-net-shape fabrication of open-porous bone replacement materials of calcium phosphate and protein
Zusammenfassung
As today’s synthetic bone implants fulfil the requirements for the repair of bone defects only in part continuous research for their improvement is ongoing. This work aims at the fabrication of bone replacement materials with bone-like properties regarding composition, structure, mechanical stability, and resorbability. As appropriate fabrication method, the slurry-based freeze gelation process was chosen. It allows the direct incorporation of active bio-relevant compounds, such as proteins, during scaffold processing. Moreover, the process enables the fabrication of complex-shaped and open-porous scaffolds. As principal components for the scaffolds calcium phosphate and protein were selected as they are biocompatible and resorbable. This work analyses the interaction between calcium phosphate and protein in suspension and investigates the suitability of the fabricated calcium phosphate/protein scaffolds as bone replacement material and drug release depot.
Table of Contents
SUMMARY ...
Schlagworte
Biocompatibility Bioresorbability Bone Replacement Calcium / Phosphate Freeze Gelation Local Drug Release Lysozyme Serum Albumin Zeta Potential- 4–14 2 BASICS 4–14
- 15–26 3 METHODS 15–26
- 27–38 4 EXPERIMENTAL 27–38
- 39–63 5 RESULTS 39–63
- 64–75 6 DISCUSSION 64–75
- 76–77 CONCLUSIONS 76–77
- 78–78 OUTLOOK 78–78
- 79–80 APPENDICES 79–80
- 81–92 REFERENCES 81–92
7 Treffer gefunden
- „... complex-shaped. Thirdly the biocompatibility of the raw components must not be impaired and toxic 2 ...” „... sintering. However sintering often reduces the biocompatibility of scaffolds as their surface becomes ...” „... biocompatibility and degradation behaviour is investigated in vitro (calcium and protein release) and in vivo in a ...”
- „... materials regarding biocompatibility, resorbability, and drug storage and release was investigated. The ...” „... biocompatibility and resorbability of the HAp/protein scaffolds with bone regeneration rates of up to 40% in 8 ...”
- „... 978-3-18-329417-6, ISSN 0178-9600, ¤ 43,00/VDI-Mitgliederpreis ¤ 38,70. Für die Dokumentation: Biocompatibility ...” „... ............................................................................................................... 21 3.3.2 Scaffolds’ biocompatibility ...” „... strength ranging from 2 to 6 MPa comparable to that of human spongious bone. Scaffold biocompatibility and ...”
- „... properties and biocompatibility. 3.3.1 Scaffold material properties 3.3.1.1 Porosity The total porosity of ...” „... ’ biocompatibility 3.3.2.1 Ultraviolet-visible spectroscopy (UV/VIS) Ultraviolet-visible spectroscopy is an ...” „... experiments Biocompatibility and resorption behaviour can be partly assessed by in vitro experiments ...”
- „... assessment In vivo experiments to initially assess composite biocompatibility and resorption behaviour were ...”
- „... regarding initial stability, biocompatibility, resorption of the HAp material and bone regeneration in an ...”
- „... in vivo assessment of the biocompatibility and resorption behaviour of hydroxyapatite/protein ...”